陈正旺

发布者：hgxyadmin发布时间：2024-03-12浏览次数：

教 师 基 本 情 况


姓 名：

陈正旺

性 别：

男

职 称：

教授

学 位：

博士

专 业：

有机化学

E-mail：

chenzwang2021@163.com

研究方向：

绿色有机合成



教育经历

2005-2008，湖南师范大学有机化学专业，获硕士学位；

2008-2011，华南理工大学应用化学专业，获博士学位；

2014-2015，加拿大McGillUniversity从事博士后研究，主要为有机合成方法学和生物质的转化研究。

工 作 经历

2011年7月开始在赣南师范大学化学化工学院工作，化学、学科教学方向硕士生导师。

课 程 教学

目前承担有机化学、有机合成、高等有机化学和合成化学等本科生以及研究生课程的教学。

教 研 及科 研 项 目

1.国家自然科学基金，21202023，基于呋喃环骨架抗血吸虫药物的设计与合成，2013-2015，主持；

  1. 江西省自然科学基金杰出青年基金项目，2021ACB213002，基于具有抗血吸虫作用的N-O骨架化合物的设计、合成与活性评价，2022-2024，主持；

  2. 江西省自然科学基金重点项目，20171ACB21048，基于过渡金属催化直接去氢分子的交叉偶联反应在抗血吸虫药物中的合成应用，2017-2019，主持；

  3. 江西省教育厅科技项目重点项目，GJJ160924，基于碳氢活化在抗血吸虫药物中的设计与合成，2016-2018，主持；

  4. 江西省教育厅科技项目，GJJ180756，氢转移策略在芳香化合物官能团化中的应用，2018-2020，主持；

  5. 江西省教育厅科技项目，GJJ201422，基于C-H活化合成烯腈类化合物及抗血吸虫研究，2020-2021，主持；

  6. 江西省自然科学基金，20114BAB213006，过渡金属催化多取代呋喃的合成研究，2011-2013，主持；

  7. 江西省教育厅项目，GJJ12579，过渡金属催化含氮化合物的合成研究，2012-2013，主持；

  8. 赣南师范大学教改课题，微型有机化学实验的探索与实践，2017-2019，主持；

  9. 赣南师范大学课程建设，“有机化学”精品在线开放课程建设，2020-2021，主持；

  10.  赣南师范大学课程建设，“现代波谱学”研究生优质课程建设，2020-2021，主持；

  11. 赣南师范大学示范课程建设，有机化学“课程思政”示范课程建设，2020-2021，主持；

  12. 赣南师范大学示范课程建设，研究生课程合成化学“课程思政”示范课程建设，2022-2023，主持；

  13. 赣南师范大学校级学位与研究生教育教学改革研究项目，“分子光谱学”课程“移动化”教学体系的建设与实践，2022-2023，主持。


主 要 成果


1.  YupingZhu, Yan-Hua Qiu, Xiao-Kang Dai, Wenjun Luo, Xiangjun Peng*,Zhengwang Chen*,Daohong Yu*. Difluoromethylated difunctionalization of alkenesunder visible light. J. Org.Chem.2024, 89,2525-2537.

2. Lipeng Long, Wenjia Wang, Yuping Zhu, Wenjun Luo, Yi Zhang, JuxiuChen, Yuting Wei, ZhengwangChen*.Benzannulation with Et3Nas 1,3-diene variants. Org.Lett., 2023, 25,7775-7779.

3.  Jinbin Zhu*, Zhengyue Li, Jiaqi Li, DuanshuaiTian, Ronghua Xu, Zhiyong Tan, ZhengwangChen*, Wenjun Tang*. Enantioselectiverhodium-catalyzed addition of arylboronic acids to N-heteroarylketones: synthesis of a-hydroxy acids.Chem. Sci., 2023,14, 1606-1612.

4.  Lipeng Long*, Xin Li, Mengshi Tu, Yekun Zhang,Liang Qiao, Wenjun Luo, Zhengwang Chen*.Hypervalent iodine(III) promoted C–H/C–Hamination/annulation tandem reactions: synthesis of benzimidazolesfrom simple anilines and aldehydes.Org. Chem.Front., 2023, 10,473-479.

5.Lipeng Long*, Xin Li, Yu Wang, Xing Su, Liang Qiao, WenjunLuo, ZhengwangChen*.Cobalt-catalyzed hypervalent iodine(III) promoted cascadeannulation reaction of anilines with formamides for2 aminobenzoxazoles synthesis. J.Org. Chem., 2023, 88,7571-7579.

6. FanglianZhang, Jiameng Liu, Wenjun Luo, Yuping Zhu, Yi Xiao, Shuxian Ma,Feixian Luo*, ZhengwangChen*. Annulationof α-bromocinnamaldehydes to access3-formyl-imidazo[1,2-α]pyridines and pyrimidines under transitionmetal-free conditions. Org.Biomol. Chem., 2023, 21,4766-4769.

7.Wenjun Luo*, Xinghua Zheng, Fanglian Zhang, Qiuya Luo, Wen-TingDeng, Lipeng Long, Daohong Yu, Zhong-Xia Wang, ZhengwangChen*. Synthesisof functionalizedtetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones throughbasepromoted annulation of quinoline-derived dipolarophiles andcyclic enaminones. Org.Biomol. Chem., 2023, 21,9524-9529.

8. Fan Xu, Fanglian Zhang, Wenjia Wang, Mingxu Yao, Xing Lin, FangYang, Yiping Qian, ZhengwangChen*.Iron(III)-catalyzed α-cyanation and carbonylation with2-pyridylacetonitrile: divergent synthesis of alfa-amino nitrilesand tetrahydroisoquinolinones.Org.Biomol. Chem., 2022, 20,7031-7035.

9.  Min Ye*, Fan, Xu, Yun Bai, Fanglian Zhang, WenjiaWang, Yiping Qian, Zhengwang Chen*.Base-promoted highly efficient synthesis of nitrile-substitutedcyclopropanes via Michael-initiated ring closure.RSC Adv., 2022,12, 28576-28579.

10.  LipengLong,*Jieyan Wang,Xin Li, Shun Feng Peng, Liang Qiao, Guotian Luo, and ZhengwangChen*. Hypervalent Iodine(III) PromotedTandem Reaction of o-Fluoroanilineswith Formamides to Construct 2-Aminobenzoxazoles. Org.Chem.Front.,2022,9, 2412-2417.

  1. Chongjiu Lu, Min Ye*, LipengLong, Yue Zheng, Jiameng Liu, Yue Zhang, ZhengwangChen*. Synthesis of unsmmetricaldiarlfumaronitriles via tandem Michael addition and oxidationunder K3Fe(CN)6/O2system.J. Org.Chem., 2022,87,1545-1553.

12.ChongjiuLu, Min Ye, Min Li, Zhijierong Zhang, YuxinHe, Lipeng Long, Zhengwang Chen*.Transition-metal-switchable divergent synthesis ofnitrile-containing pyrazolo[1,5-ɑ]pyridinesand indolizines. Chin.Chem. Lett., 2021,32, 3967-3971.

13.LipengLong*, Jieyan Wang,Liuqing Gu, Shiguang Yang, Liang Qiao, Guotian Luo,Zhengwang Chen*.Hypervalent iodine(III)-promoted radical oxidative C-H annulationof arylamines with ɑ-ketoacids. J. Org. Chem.,2021,86,12084-12092.

14.XiaoweiWen, Xiaojuan Liu, Zhiqi Yang, Menglan Xie,Yuxi Liu, Lipeng Long, Zhengwang Chen*.“On water”nano-Cu2O-catalyzedCO-free one-pot multicomponent cascadecyanation-annulation-aminolysis reaction toward phthalimides.Org. Biomol. Chem., 2021,19,1738-1743.

15.ZunxianLin,  Zhengwang Chen*,Guanlin Zhong, Lipeng Long, Peng He, Guotian Luo*. Aporhyrin-based 5-fluorouracil and its metal complexes: synthesis,optical properties, and antitumor activity. ChemistrySelect.2021, 6,6944-6948.

16.Zhengwang Chen*,XiaoweiWen, Weiping Zheng, Ruolan He, Dou Chen, Dingsheng Cao, LipengLong, Min Ye*. Acylcyanides as bifunctional reagent: application in copper-catalyzedcyanoamidation and cyanoesterification reaction. J.Org. Chem., 2020,85,5691-5701.

17.  Tanggao Liu,Fan Xu, Xiaojuan Liu, Zhiqing Huang,LipengLong, Guohai Xu, Hong Xiao, ZhengwangChen*.Switchingthe regioselectivity access to pyrroles and isoquinolines fromketoximes acetates and ynals. ACSOmega, 2020,5, 31473-31484.

18.  Jing Zheng, Linli Chen,Xiaojuan Liu, Wenju Xu, Yan Wang, Qin He, Hanqing Liu, Min Ye,Guotian Luo*, Zhengwang Chen*.I2-catalyzedintermolecular cyclization to synthesis of 3-acylated indolizines.ChemistrySelect.2021, 6,6944-6948.

19.Zhengwang Chen*,Pei Liang, Fan Xu, Zhen Deng, Lipeng Long,Guotian Luo, Min Ye*. Metal-free aminothiation of alkynes:three-component tandem annulation toward indolizine thiones from2-alkylpyridines, ynals, and elemental sulfur. J.Org. Chem., 2019,84,12639-12647.

20.Zhengwang Chen*,Pei Liang, Fan Xu, Rulin Qiu, Qi Tan, LipengLong, Min Ye*. Lewisacid-catalyzed intermolecular annulation: three-component reactiontoward imidazo[1,2-ɑ]pyridine thiones.J.Org. Chem., 2019,84,9369-9377.

21.Zhengwang Chen*,Pei Liang, Xiaoyue Ma, HaiqingLuo, Guohai Xu, Tanggao Liu, Xiaowei Wen, Jing Zheng, HuiYe*. Catalyst-freeannulation of 2-pyridylacetates and ynals with molecular oxygen:an access to 3-acylated indolizines.J.Org. Chem., 2019,84,1630-1639.

22.  Zhengwang Chen*,Botao Liu, Pei Liang, Haiqing Luo, Jing Zheng, Xiaowei Wen,Tanggao Liu, Guotian Luo, Min Ye. Construction of N-S and C-Nbonds from reactions of benzofuroxans with DMSO or THF. ACSOmega, 2019,4, 281-291.

23.  Zhengwang Chen*,Tanggao Liu, Miaoyue Ma, Pei Liang, Lipeng Long, Min Ye. A one-potSonogashira coupling and annulation reaction: an efficient routetoward 4H-quinolizin-4-ones.Synlett, 2019,30, 863-867.

24.  Zhengwang Chen*,Jiayang Liu, Caiju Jin, Qi Tan, Min Ye. Transition-metal-freehighly efficient synthesis of 2-pyridones from beta-keto amidesand ynals. Tetrahedron Lett.,2019,60, 1265-1267.

25.Zhengwang Chen*,Pei Liang, Jing Zheng, Zhonggao Zhou, XiaoweiWen, Tanggao Liu, Min Ye*.Cyanide-free Ce(III)-catalyzed highly efficient synthesis ofα-iminonitriles from2-aminopyridines and nitroalkenes via intermolecular dehydrationreaction.ACS Omega,2018,3,12520-12529.

26.Zhengwang Chen*,Pei Liang, Botao Liu, HaiqingLuo, Jing Zheng, Xiaowei Wen, Tanggao Liu,MinYe*. A facile tandemdecyanation/cyanation reaction of α-iminonitrilestoward cyano-substituted amides.Org.Biomol. Chem., 2018,16,8481-8485.

27.Zhengwang Chen*,Xiaowei Wen, Yiping Qian, Pei Liang, Botao Liu, MinYe*. Ce(III)-catalyzed highly efficientsynthesis of pyridyl benzamides from aminopyridines andnitroolefins without external oxidants. Org.Biomol. Chem., 2018,16,1247-1251.

28.Zhengwang Chen*,Botao Liu, Pei Liang, Zhixiong Yang, Min Ye*.Iron(III)-catalyzed synthesis of 3-aroylimidazo[1,2-α]pyridinesfrom 2-aminopyridines and ynals. TetrahedronLett., 2018,59, 667-670.

29. LiliJiang, Xiangjun Peng, Panpan Huang, ZhengwangChen*, Liangxian Liu*.TEMPO-catalyzed oxidative dimerization and cyanation of indolesfor the synthesis of2-(1H-indol-3-yl-3-oxoindoline-2-carbonitriles.Tetrahedron,2017, 73,1389-1396.

30. Zhengwang Chen*,Yuelu Wen, Yejuan Fu, Hai Chen, Min Ye,Guotian Luo*. Grapheneoxide: an efficient acid catalyst for the construction of estersfrom acids and alcohols.Synlett,2017, 28,981-985.

31. Zhengwang Chen*,Yuelu Wen, Hao Ding, Guotian Luo, Min Ye,Liangxian Liu, Jun Xue*.Silver-catalyzed highly efficient synthesis ofpyrido[1,2-α]pyrimidin-4-onesfrom 2-aminopyridines and alkynoates.Tetrahedron Lett.,2017, 58,13-16.

32. Zhengwang Chen*,Yuelu Wen, Guotian Luo,Min Ye, Qinghao Wang*. Transition-metal-freeC-C bond cleavage and formation: efficient synthesis of2,3-diarylimidazo[1,2-α]pyridinesfrom 2-aminopyridnes and alkynoates.RSC Adv.,2016, 6,86464-86467.

33. Zhengwang Chen#,Huiying Zeng#,Simon A. Girard, Feng Wang, Ning Chen,Chao-Jun Li*. Formal direct cross-coupling ofphenols with amines. Angew.Chem. Int. Ed.,2015,54, 14487-14491. (Hot paper;Highlighted by Synfact,2016,12,0205;C&EN, 2015, 93, 31; ChemistryWorld, 2016, April 26 )

34. Zhengwang Chen,Huiying Zeng, Hang Gong, Haining Wang, Chao-Jun Li*.Palladium-catalyzed reductive coupling ofphenols with anilines and amines:efficientconversion of phenolic lignin model monomers and analogues tocyclohexylamines. Chem.Sci., 2015,6, 4174-4178.

35.JiayiZhu, Yu Chen, Feng Lin, Baoshuang wang,ZhengwangChen*,Liangxian Liu*. NiSO4-catalyzedC-H activation/C-S cross-coupling of 1,2,3-triazole N-oxideswith thiols. Org. Biomol. Chem.,2015, 13,3711-3720.

36.JiayiZhu, Yubo Kong, Feng Lin, Baoshuang wang,ZhengwangChen*,Liangxian Liu*.Copper-catalyzeddirect amination of 1,2,3-triazole N-oxidesby C-H activation and C-N coupling. Eur. J.Org. Chem, 2015,(7): 1507-1515.

37.ZhengwangChen*, MiaotingLuo, Yuelu Wen, Guotian Luo, Liangxian Liu*.Transition-metal-freesemihydrogenation ofdiarylalkynes: Highlystereoselective synthesisof trans-alkenes usingNa2S·9H2O.Org. Lett.,2014, 16(11),3020-3023.

38.ZhengwangChen*,Miaoting Luo, Yuelu Wen, Min Ye, Zhonggao Zhou, Liangxian Liu*.A highly efficientsynthesis of2,5-disubstituted furansfrom enyne acetatescatalyzed by Lewis acidand palladium.Synlett., 2014,(25), 2341-2344.

39.ZhengwangChen*, Dong-Nai Ye,Min Ye, Zhong-Gao Zhou, Shen-Huan Li, Liang-Xian Liu*.AgF/TFA-promoted highly efficient synthesis ofα-haloketones fromhaloalkynes. TetrahedronLett., 2014,55(7), 1373-1375.

40.JunXue, Miaoting Luo, Yuelu Wen, Min Ye, Liangxian Liu, ZhengwangChen*.Transition-metal-catalyzedsynthesis of 1,3-diynesand ynamides from2-bromo-1-iodoalkenes.Synthesis, 2014,(46), 3191-3198.

41.ZhengwangChen*, Dong-Nai Ye,Yi-Ping Qian, Min Ye, Liang-Xian Liu*.Highly efficient AgBF4-catalyzedsynthesis of methyl ketones from terminal alkynes. Tetrahedron,2013, 69(30),6116-6120.

42.ZhengwangChen*, Dongnai Ye,Guohai Xu, Min Ye, Liangxian Liu*.Highly efficient synthesis of 2,5-disubstituted pyrazines from(Z)-ß-haloenol acetates. Org. Biomol.Chem., 2013, 11,6699-6702.

43. ZhengwangChen*, Dong-Nai Ye,Min Ye, Liang-Xian Liu*.Palladium-catalzyed oxidation of benzyl ketones to synthesis ofacetoxy ketones using molecular oxygen. Chem.Lett.,2013,42(11),1388-1390.

44. Zhengwang Chen,Wei Zeng, Huanfeng Jiang*,Liangxian Liu. Cu(II)-catalyzedsynthesis ofnaphthalene-1,3-diamine derivativesfrom haloalkynes andamines.Org. Lett.,2012, 14(21),5385-5387.

45. Zhengwang Chen, Gao Huang, HuanfengJiang*, Xiaoyan Pan.Sonogashira reaction of the (Z)-β-haloenolacetates to form the (Z)-eneyneacetates and followed to form the 2,3,5-trisubstituted furansthrough the iodocyclization reaction. J.Org. Chem., 2011,76(4), 1134-1139.

46.  Zhengwang Chen,Huanfeng Jiang*, XiaoyanPan, Zaijun He. Practical synthesis of amides from alkynylbromides, amines, and water. Tetrahedron,2011, 67(33),5920-5927.

47.  Zhengwang Chen,Jinghao Li, Huanfeng Jiang*,Shifa Zhu, Yibiao Li, and Chaorong Qi.Silver-catalyzed difunctionalization of terminal alkynes: highlyregio- and stereoselective synthesis of (Z)-haloenol acetates.Org. Lett.,2010,12(14), 3262-3265.(Highlighted by SYNFACTS, 2010, 1278)

48.Zhengwang Chen,Huanfeng Jiang*, AzhongWang, and Shaorong Yang.Transition-metal-free homocoupling of1-haloalkynes: a facile synthesis of symmetrical 1,3-diynes.J. Org. Chem.,2010, 75(19),6700-6703.

49.Zhengwang Chen,Huanfeng Jiang*,Yibiao Li, and Chaorong Qi. Highly efficienttwo-step synthesis of (Z)-2-halo-1-iodoalkenes from terminalalkynes.Chem.Commun., 2010,46, 8049-8051.



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